DNA sequencing of the BFMI, a juvenile obesity mouse model

DNA sequencing data of the Berlin Fat Mouse Inbred (BFMI) mouse, a mouse model for polygenic obesity. The inbred BFMI strains generated from the BFM outbred population, develops obesity under a standard maintenance diet at juvenile age of 6 weeks. Besides high total body fat content of ~25% in male mice, the mice show reduced insulin sensitivity and elevated serum triglyceride levels at 10 weeks. The impaired insulin sensitivity of BFMI mice is accompanied by high insulin-like growth factor-1 serum levels, which likely compensate for the low insulin sensitivity and contribute to normal glucose homeostasis.

本数据集为柏林肥胖近交系小鼠（Berlin Fat Mouse Inbred, BFMI）的DNA测序数据，该品系是多基因肥胖的小鼠模型。BFMI近交系由BFM远交种群培育而来，在标准维持日粮饲喂条件下，小鼠于6周龄幼年期即可出现肥胖表型。雄性小鼠体内总脂肪含量可达约25%，且在10周龄时表现出胰岛素敏感性降低与血清甘油三酯水平升高的代谢异常。BFMI小鼠的胰岛素敏感性损伤伴随血清胰岛素样生长因子-1（insulin-like growth factor-1）水平升高，这一现象可能代偿了较低的胰岛素敏感性，有助于维持正常的葡萄糖稳态。