Increased prevalence of insecticide resistance in Anopheles coluzzii populations in the city of Yaoundé, Cameroon and influence on pyrethroid-only treated bed net efficacy

The present study assessed the efficacy of such LLINs against a multiple-resistant population of the major malaria vector, Anopheles coluzzii, in the city of Yaoundé via a cone bioassay and release-recapture experimental hut trial. Susceptibility of field mosquitoes in Yaoundé to pyrethroids, DDT, carbamates and organophosphate insecticides was investigated using WHO bioassay tube tests. Mechanisms of insecticide resistance were characterised molecularly. (MapVEu VBP0000763)

本研究通过锥形生物测定法与释放-重捕实验小屋试验，评估了此类长效杀虫蚊帐（Long-Lasting Insecticidal Nets, LLINs）对喀麦隆雅温得市主要疟疾传播媒介科卢齐按蚊（Anopheles coluzzii）多重抗性种群的防控效果。本研究采用世界卫生组织（World Health Organization, WHO）生物测定试管试验，调查了雅温得野外采集蚊虫对拟除虫菊酯、滴滴涕（DDT）、氨基甲酸酯类与有机磷类杀虫剂的敏感性，并通过分子生物学手段对杀虫剂抗性的作用机制进行了表征分析。(MapVEu VBP0000763)