Table S1 - Molecular Topology as Novel Strategy for Discovery of Drugs with Aβ Lowering and Anti-Aggregation Dual Activities for Alzheimer’s Disease

Aβ-lowering activity and anti-aggregation activity of the 8 lead compounds. Data presented for Ab-lowering is based on 100 uM testing compound in primary neurons derived from Tg2576 mice and anti-aggregation is based on equal molar ratio of compound and Ab (see material and methods for experiment details).
(PPTX)

8种先导化合物的降β淀粉样蛋白（Aβ）活性与抗聚集活性。其中降Aβ活性数据基于在Tg2576小鼠来源的原代神经元中以100 μM浓度测试化合物所得结果，抗聚集活性数据则基于化合物与Aβ等摩尔比的实验条件，实验细节详见材料与方法部分。（PPTX）