3,5-T2 induce Axolotl metamorphosis

Thyroid hormones (TH) regulate tissue remodeling processes during early- and post-embryonic stages in vertebrates. The Mexican axolotl (Ambystoma mexicanum) is a neotenic species that has lost the ability to undergo spontaneous metamorphosis, a life cycle transition critically controlled by TH. However, it can be artificially induced by exogenous administration of thyroxine (T4) and 3,3',5-triiodo-L-thyronine (T3). Here, we ask whether 3,5-diiodo-L-thyronine (3,5-T2), another less well known TH derivative, can also induce metamorphosis and what the specific transcriptional responses.

甲状腺激素（Thyroid hormones, TH）可调控脊椎动物胚胎早期及胚后阶段的组织重塑过程。美西钝口螈（Ambystoma mexicanum）是一种幼态持续物种，丧失了自然变态发育的能力——而该生命周期转变过程恰恰受甲状腺激素的关键调控。不过，可通过外源性给予甲状腺素（T4）与3,3',5-三碘-L-甲状腺原氨酸（T3）人工诱导其变态发育。本研究旨在探究另一种鲜为人知的甲状腺激素衍生物3,5-二碘-L-甲状腺原氨酸（3,5-T2）是否同样可诱导美西钝口螈的变态发育，以及其对应的特异性转录响应。