Low muscle mass and muscle quality are associated with mortality after Transcatheter Aortic Valve Implantation

Not all patients with severe aortic valve stenosis benefit from Transcatheter Aortic Valve Implantation (TAVI). Especially frail patients, with low resilience due to low muscle mass or muscle quality may be at risk of mortality, despite a technically successful procedure.<br> Aim of this study is to determine if automatically assessed muscle mass and muscle quality are associated with long-term mortality after TAVI. <br> The study had an observation design. Including 1405 patients with servere aortic stenosis undergoing TAVI, from January 2010 until January 2020. With the deep-learning software of Quantib (research.quantib.com) muscle area, average density of muscle area in Hounsfield Units and Intermuscular Adipose Tissue was determined. Patients were followed for approximately 5-year. <br> 1. Data of study <br> Because of the sensitive nature of the data, the data is confidential and will be shared only under strict conditions. For more information contact: [e-mail], Cardiology, Amsterdam UMC, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands. <br> Syntax used for analysis can be found on GitHub: https://github.com/Dennisvanerck/Quantib_mortality <br>

并非所有重度主动脉瓣狭窄患者都能从经导管主动脉瓣植入术（Transcatheter Aortic Valve Implantation, TAVI）中获益。尤其是因肌肉量低或肌肉质量差而韧性不足的虚弱患者，即便手术技术成功，仍可能面临死亡风险。

本研究旨在明确自动评估的肌肉量与肌肉质量是否与TAVI术后长期死亡率相关。

本研究采用观察性设计，纳入2010年1月至2020年1月期间接受TAVI治疗的1405例重度主动脉瓣狭窄患者。通过Quantib公司的深度学习软件（research.quantib.com），测定了肌肉面积、肌肉区域的平均亨斯菲尔德单位（Hounsfield Units）密度及肌间脂肪组织。患者随访时间约为5年。

1. 研究数据

由于数据具有敏感性，所有数据均严格保密，仅在特定条件下对外共享。如需更多信息，请联系：[e-mail]，荷兰阿姆斯特丹大学医学中心（Amsterdam UMC）心脏病科，地址：Meibergdreef 9, 1105AZ Amsterdam, The Netherlands。

分析所用语法可在GitHub平台获取：https://github.com/Dennisvanerck/Quantib_mortality