Genome-wide epigenetic adaptation to high altitude: an exploratory DNA methylation profile analysis in snub-nosed monkeys

DNA methylation has been proved to have a crucial role in environmental adaptations. Here, using whole-genome bisulfite sequencing method, we acquired the genome-wide DNA methylation profiles of Yunnan snub-nosed monkeys (Rhinopithecus bieti), which are known as the nohuman primates that inhabit the highest altitude, and their close relatives, the golden snub-nosed monkey (R. roxellana).

DNA甲基化（DNA methylation）已被证实对环境适应具有关键作用。本研究采用全基因组亚硫酸氢盐测序（whole-genome bisulfite sequencing）方法，获取了栖息于已知海拔最高的非人灵长类——滇金丝猴（Rhinopithecus bieti）及其近缘物种川金丝猴（R. roxellana）的全基因组DNA甲基化谱。