Gene expressioin signatures at basal level in human lymphoblastoid cell lines with different ataxia telangiectasia-mutated (ATM) genotypes

Transcriptional profiling of human lymphoblastoid cell lines with different ATM genotypes at basal level was compared to extract gene expression signatures that can identify ataxia telangiectasia (AT) carries from non AT carries and AT patients. Biological replicates: 4; Technical replicates: 2 with C3 and C5 dye swap.

本研究对基线水平下携带不同ATM基因型的人类淋巴母细胞系（human lymphoblastoid cell lines）开展转录谱分析（transcriptional profiling），通过组间比较筛选出可区分共济失调毛细血管扩张症（ataxia telangiectasia, AT）携带者、非AT携带者与AT患者的基因表达特征。实验设置生物学重复4次；技术重复2次，采用C3与C5染料互换（dye swap）的实验策略。