Supplementary Material for: Campylobacter colitis as a trigger for atypical hemolytic uremic syndrome: about one case

Hemolytic uremic syndrome (HUS) belongs to the family of thrombotic microangiopathies (TMA). The diagnosis of HUS is suggested by the following triad: mechanical hemolytic anemia, thrombocytopenia and acute renal failure. In general, two types of HUS are distinguished: typical HUS, usually caused by Shiga toxin–producing Escherichia coli (STEC), and atypical HUS (aHUS) caused by deregulated complement activation. Here we present the case of a 17-year-old adolescent with factor H-associated aHUS, whose initial presentation was that of a typical diarrhea-associated HUS. The purpose of this article is to draw attention to this peculiar onset of an authentic aHUS and to stress the importance of analysing the alternate pathway of complement if the course of a supposedly typical HUS turns out to be unusual.

溶血尿毒症综合征（Hemolytic uremic syndrome, HUS）隶属于血栓性微血管病（thrombotic microangiopathies, TMA）家族。该病的诊断可通过下述三联征提示：机械性溶血性贫血、血小板减少症与急性肾衰竭。目前通常将HUS分为两类：一类为典型HUS，多由产志贺毒素大肠埃希菌（Shiga toxin–producing Escherichia coli, STEC）引发；另一类为非典型HUS（atypical HUS, aHUS），其病因系补体激活失调。本文报告1例17岁青少年罹患补体因子H相关性aHUS的病例，该患者初始临床表现符合典型腹泻相关性HUS。本文旨在提请学界关注这种以典型HUS为初始表现的真性aHUS罕见起病形式，并强调若疑似典型HUS的病程出现异常，需重视补体旁路途径的相关检测分析。