Table 2_Modulating TRPV1 and TRPA1 channels: a viable strategy for treating asthma using Chinese herbal medicines.xls

Asthma represents a significant global health challenge, imposing a substantial burden on society worldwide. Over the past decades, the development of asthma medications has significantly reduced asthma-related mortality. However, current pharmacological treatment regimens have not yet demonstrated the capacity to induce a durable remission of asthma. Transient receptor potential channels, specifically vanilloid receptor 1 (TRPV1) and ankyrin 1 (TRPA1), are polymodal sensory channels extensively distributed in the lungs and represent promising therapeutic targets for asthma. Increasing evidence suggests that Chinese herbal medicines (CHM) exert beneficial effects in asthma treatment by modulating TRPV1/TRPA1. Therefore, this study systematically analyzed 134 articles covering the pathogenesis of asthma, current treatment strategies, the role of TRPV1/TRPA1 in asthma, and the modulation of TRPV1/TRPA1 by Chinese herbal medicines in asthma. In summary, our review comprehensively elaborates on how CHM modulates TRPV1/TRPA1 channels to alleviate pulmonary inflammation. These findings provide viable options for asthma drug discovery and establish the foundation for developing effective CHM-based therapeutics.

哮喘是一项重大的全球公共卫生难题，给全球社会带来了沉重的疾病负担。近数十年来，哮喘治疗药物的研发已显著降低了哮喘相关死亡率。然而，当前的药物治疗方案仍无法实现哮喘的持久缓解。瞬时受体电位通道（Transient receptor potential channels），具体包括香草酸受体1（TRPV1）与锚蛋白受体1（TRPA1），属于广泛分布于肺部的多模态感觉通道，是极具潜力的哮喘治疗靶点。越来越多的研究证据表明，中草药（Chinese herbal medicines, CHM）可通过调控TRPV1/TRPA1通道，在哮喘治疗中发挥有益作用。因此，本研究系统分析了134篇相关文献，内容涵盖哮喘的发病机制、现有临床治疗策略、TRPV1与TRPA1在哮喘中的作用，以及中草药对哮喘中TRPV1/TRPA1通道的调控机制。综上，本综述全面阐述了中草药通过调控TRPV1/TRPA1通道以减轻肺部炎症的具体路径与机制。本研究结果为哮喘治疗药物的研发提供了可行的备选方案，也为开发高效的中草药靶向疗法奠定了坚实基础。