Transcriptome data of Penicillium citrinum regulated by pH. Penicillium citrinum

Penicillium citrinum X9-4, which was isolated from infected grapes by our laboratory, produced the highest amount of OTA at pH 5 in culture media, and toxin-production was restrained under acidic environment (pH 3). It revealed the possible mechanism of OTA biosynthesis and metabolic regulation in P. citrinum by transcriptomics, and investigated the reason of OTA biosynthesis was restrained in P. citrinum when cultured under acidic environment. Overall design: Penicillium citrinum cultured at pH 3 (control, non OTA production) and pH 5 (produce highest amount of OTA)

本实验室从受侵染葡萄中分离得到桔青霉（Penicillium citrinum）X9-4菌株。该菌株在pH 5的培养基中可合成产量最高的赭曲霉毒素A (OTA)，而在酸性环境（pH 3）下其产毒过程受到抑制。本研究通过转录组学分析，揭示了桔青霉中OTA生物合成与代谢调控的潜在机制，并探究了酸性培养条件下桔青霉OTA生物合成受抑制的原因。整体实验设计：将桔青霉分别置于pH 3（对照组，不产生OTA）与pH 5（可产生最高产量OTA）的培养基中培养。