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<b>Research Background</b>: Septic shock is a life-threatening condition caused by severe infection, particularly dangerous in children with high mortality and complication rates. Blood purification is an emerging treatment method that helps control infection and improve patient outcomes by removing toxins and inflammatory factors from the body. However, the efficacy of treatment is still controversial.Common blood purification methods include CVVHDF and HP. CVVHDF primarily removes medium and small molecular substances, while HP can directly adsorb and remove large molecular inflammatory factors. <b>Research Objective</b>: This study aims to evaluate the efficacy of blood purification treatment (including CVVHDF combined with HP) in children with septic shock, focusing on the removal of inflammatory factors and its impact on prognosis.<b>Research Methods</b>: The study included 66 children diagnosed with septic shock, divided into a blood purification treatment group and a conventional treatment group. Comparative analysis was conducted on the changes in inflammatory factors before and after treatment, 28-day mortality rate,etc.<b>Research Results</b>: The results showed that the levels of inflammatory factors significantly decreased in the blood purification treatment group after treatment, with a notable reduction in hospitalization and ICU stay duration compared to the conventional treatment group. The 28-day mortality rate was also significantly lower in the blood purification treatment group.<b>Research Conclusion</b>: Blood purification treatment has a significant advantage in quickly and effectively removing inflammatory factors in children with septic shock, reducing mortality, and improving prognosis. Therefore, it is recommended to initiate blood purification treatment for children with septic shock to improve treatment outcomes.<br><br><br><br><br><br>

<b>研究背景</b>: 脓毒性休克（Septic shock）是由严重感染引起的危及生命的病症，在儿童中尤为危险，具有较高的死亡率和并发症发生率。血液净化（blood purification）是一种新兴治疗方法，通过清除体内毒素和炎症因子来帮助控制感染并改善患者预后。然而，其治疗效果仍存在争议。常见的血液净化方法包括CVVHDF和HP。CVVHDF主要清除中小分子物质，而HP可直接吸附并清除大分子炎症因子。<b>研究目的</b>: 本研究旨在评估血液净化治疗（包括CVVHDF联合HP）在儿童脓毒性休克中的疗效，重点关注炎症因子的清除及其对预后的影响。<b>研究方法</b>: 本研究纳入66例确诊为脓毒性休克的儿童，将其分为血液净化治疗组和常规治疗组。对治疗前后炎症因子的变化、28天死亡率等指标进行对比分析。<b>研究结果</b>: 结果显示，血液净化治疗组治疗后炎症因子水平显著降低，与常规治疗组相比，住院时间和ICU停留时间显著缩短，且28天死亡率也显著降低。<b>研究结论</b>: 血液净化治疗在快速有效清除儿童脓毒性休克患者体内炎症因子、降低死亡率及改善预后方面具有显著优势。因此，建议对儿童脓毒性休克患者启动血液净化治疗以改善治疗效果。