TEMPO对小鼠淋巴瘤细胞的比较基因毒性研究补充数据

本数据集为TEMPO及其三种衍生物（4-羟基-TEMPO、4-氧代-TEMPO、4-甲氧基-TEMPO）的遗传毒性比较研究补充数据。通过小鼠淋巴瘤试验（MLA）和彗星试验，评估了四种硝氧化物在有无S9代谢活化条件下的细胞毒性、致突变性及DNA损伤效应，并通过PROAST基准剂量软件分析剂量反应关系，确定其作用模式及突变特征。 论文“Comparative genotoxicity of TEMPO and three of its derivatives in mouse lymphoma cells”

This dataset comprises supplementary data for the comparative genotoxicity investigation of TEMPO and its three derivatives: 4-hydroxy-TEMPO, 4-oxo-TEMPO, and 4-methoxy-TEMPO. The cytotoxicity, mutagenicity, and DNA damaging effects of the four nitroxides were evaluated using the mouse lymphoma assay (MLA) and comet assay, both in the presence and absence of S9 metabolic activation. Dose-response relationships were analyzed using the PROAST benchmark dose software to elucidate their modes of action and mutagenic profiles. The corresponding peer-reviewed paper is titled "Comparative genotoxicity of TEMPO and three of its derivatives in mouse lymphoma cells"