Table_1_The Impact of Frailty on Adverse Outcomes in Geriatric Hip Fracture Patients: A Systematic Review and Meta-Analysis.pdf

ObjectiveWith an aging population and advances in medicine, more research focuses on health and longevity in geriatric adults. Recently, frailty has gradually emerged to assess physical conditions. Frailty can be generally described as a multi-dimensional situation of increased vulnerabilities to both endogenous and exogenous stressors. The objective of the review was to evaluate the predictive value of frailty on adverse outcomes in geriatric hip fracture patients.
Materials and MethodsWe searched PubMed, Embase, Web of Science, and the Cochrane library for relevant literature about the connection between frailty and poor outcomes in hip fracture elders.
ResultsEleven studies involving a total of 45,979 participants were selected in our study. Our results indicated that frailty could significantly predict postoperative and in-patient complications (OR, 1.46; 95% CI, 1.13–1.90; I2 = 77.4%). Frail elders had higher risk of inpatient mortality (OR, 1.68; 95% CI, 1.26–2.25; I2 = 0.0%), 6-month mortality (OR, 1.46; 95% CI, 1.25–1.72; I2 = 0.0%) and ≥1-year mortality (OR, 2.24; 95% CI, 1.66–3.04; I2 = 91.3%). Furthermore, the risk of prolonged hospital stays was 1.15 times more likely in frail patients (95% CI, 1.03–1.28; I2 = 14.8%).
ConclusionFrailty can predict adverse outcomes effectively in geriatric hip fracture patients.
Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/#recordDetails.

研究背景与目的：随着人口老龄化加剧与医学技术进步，老年人群健康与长寿相关研究日益受到重视。近年来，衰弱（frailty）逐渐成为评估老年个体身体状况的重要指标。衰弱通常可被定义为一种多维度的、机体对内源性与外源性应激源易感性升高的状态。本综述旨在评估衰弱对老年髋部骨折患者不良临床结局的预测价值。

材料与方法：我们在PubMed、Embase、Web of Science及Cochrane图书馆中检索有关衰弱与老年髋部骨折患者不良结局相关性的相关文献。

研究结果：本研究共纳入11项研究，涉及总计45979名受试者。分析结果显示，衰弱可显著预测术后及住院期间并发症（比值比OR=1.46，95%置信区间CI：1.13~1.90；I²=77.4%）。衰弱老年患者的住院期间死亡率（OR=1.68，95%CI：1.26~2.25；I²=0.0%）、术后6个月死亡率（OR=1.46，95%CI：1.25~1.72；I²=0.0%）及≥1年死亡率（OR=2.24，95%CI：1.66~3.04；I²=91.3%）均显著升高。此外，衰弱患者的住院时间延长风险较非衰弱患者升高1.15倍（95%CI：1.03~1.28；I²=14.8%）。

研究结论：衰弱可有效预测老年髋部骨折患者的不良临床结局。

系统综述注册信息：https://www.crd.york.ac.uk/PROSPERO/#recordDetails。