Cancer Cells Resistant to Immune Checkpoint Blockade Acquire Interferon-Associated Epigenetic Memory to Sustain T Cell Dysfunction (RNA-Seq)

We show that across human and/or mouse tumors immune dysfunction is associated with cancer cells acquiring epigenetic features of inflammatory memory. Here, inflammatory memory domains, many of which are initiated by chronic IFNG, are established by STAT1 and IRF3 and link H3K4me1-marked chromatin accessibility to increased expression of a subset of IFN-stimulated genes (ISGs). Overall design: RNA-Seq

本研究证实，在人类及/或小鼠肿瘤中，免疫功能异常与癌细胞获得炎性记忆（inflammatory memory）表观遗传特征显著相关。本研究中的炎性记忆结构域多由慢性IFNG触发，由STAT1与IRF3介导建立，并将H3K4me1标记的染色质开放性与一类干扰素刺激基因（IFN-stimulated genes, ISGs）子集的表达上调建立关联。实验整体设计：RNA测序（RNA-Seq）