Progressive kidney disease is suppressed by a small molecule inhibitor of TRPC5

Conclusions: In short, the in vivo gene expression profiles support a Rac1-TRPC5 disease-promoting pathway in proteinuric kidney disease that is reversed by treatment with AC1903.结论：简言之，体内基因表达谱证实，Rac1-TRPC5通路可促进蛋白尿性肾病的发生发展，且该致病效应可通过AC1903治疗得到逆转。