PGE2

The PGE2 network depicts the pathways exerting regulatory control of PGE2 in the context of cellular proliferation. The network includes cAMP-mediated activation of PKA-, Epac/Rap1- and Tiam1/Vav2-dependent pathways of Rac1 activation.

PGE2（前列腺素E2，Prostaglandin E2）网络刻画了细胞增殖背景下对PGE2施加调控作用的信号通路。该网络包含由环磷酸腺苷（cAMP，cyclic adenosine monophosphate）介导激活的、分别依赖蛋白激酶A（PKA，Protein Kinase A）、Epac/Rap1以及Tiam1/Vav2的Rac1（Ras相关C3肉毒杆菌毒素底物1，Ras-related C3 botulinum toxin substrate 1）激活通路。