Role of GDF10 for axonal sprouting and functional recovery after stroke. Role of GDF10 for axonal sprouting and functional recovery after stroke

GDF10 controls a unique transcriptome, which coordinately regulates several molecular signaling systems that provide insights into how this molecule induces a neuronal growth state and is distinct from other developmental and adult plasticity phenotypes. Overall design: 4 conditions with three replicates: P4: animal control WT: adult animal control PT: adult animal stroke PT-GDF10: GDF10 siRNA adult animal stroke

GDF10可调控一套独特的转录组（transcriptome），该转录组协同调控多条分子信号通路，为阐明该分子诱导神经元生长状态的潜在机制提供了重要见解，且其调控模式与其他发育性及成年性可塑性表型存在显著差异。实验设计概述：共设置4组处理，每组设置3次生物学重复：P4组：出生后4天幼年动物对照组；WT组：成年野生型动物对照组；PT组：成年动物卒中模型组；PT-GDF10组：经GDF10小干扰RNA（siRNA）处理的成年卒中模型动物组。