Supplementary tables: Characteristics, completion and publication of PROSPERO records in regional anesthesia for acute perioperative pain

These are peer-reviewed supplementary materials for the article 'Characteristics, completion and publication of PROSPERO records in regional anesthesia for acute perioperative pain' published in the Journal of Comparative Effectiveness Research.Supplementary table 1: List of comparators in PROSPERO records in regional anesthesia.Supplementary table 2: List of main efficacy outcomes in PROSPERO records in regional anesthesia.Supplementary Table 3: Safety outcomes planned as one of the main outcomes in PROSPERO records in regional anesthesia.Aim: We analyzed characteristics and completion status of Systematic Reviews (SRs) about regional anesthesia for acute perioperative pain relief registered in PROSPERO. Materials & methods: PROSPERO was searched on 5 January 2022. Characteristics of PROSPERO records, completion status and publication information were extracted. PubMed and Google Scholar were searched by 31 May 2022, for additional published SRs. The inconsistency of PROSPERO records’ status was analyzed by comparing the most recent PROSPERO statuswith subsequent publication of completed SR. Time-to-publication was calculated. Results: Almost half of 174 included PROSPERO records (49%) were registered in 2021. A median of 3 (IQR: 2–4.75) authors, and a search of 4 information sources (IQR: 3–5) was planned. At first registration, 51 (29%) records had already started or completed formal screening. PROSPERO records included mostly adults (48%) undergoing trunk blocks (56%), with pain intensity (74%) as a main outcome. 147 (84%) PROSPERO records had a status “ongoing”. Yet, 71 (41%) PROSPERO records were completed SRs, published after a median of 291 days. Inconsistency in status was found in 34% of PROSPERO records. Conclusion: Despite an increase in PROSPERO registrations about regional anesthesia, most were not published, and a third had inaccurate status.

本数据集为发表于《比较有效性研究杂志》的论文《区域麻醉中急性围手术期疼痛的PROSPERO记录的特性、完成情况及发表情况》的同行评审补充材料。补充表1：PROSPERO区域麻醉记录中的比较药物清单。补充表2：PROSPERO区域麻醉记录中的主要疗效结果清单。补充表3：作为PROSPERO区域麻醉记录中主要结果之一计划的安全结果。研究目的：本研究旨在分析关于区域麻醉用于急性围手术期疼痛缓解的系统评价（SR）在PROSPERO注册中的特性及完成情况。材料与方法：于2022年1月5日对PROSPERO进行了检索。提取了PROSPERO记录的特性、完成状态及发表信息。至2022年5月31日，通过PubMed和Google Scholar检索了额外的已发表SR。通过比较PROSPERO记录的最新状态与完成SR的后续出版物，分析了PROSPERO记录状态的矛盾性。计算了发表时间。结果：在174项纳入的PROSPERO记录中，近一半（49%）于2021年注册。平均作者人数为3人（中位数：2–4.75），计划检索4个信息来源（中位数：3–5）。在首次注册时，已有51（29%）的记录开始或完成了正式筛选。PROSPERO记录主要包括接受躯干神经阻滞的成年人（48%），以疼痛强度（74%）作为主要结果。147（84%）的PROSPERO记录状态为“进行中”。然而，71（41%）的PROSPERO记录为已完成SR，并在中位数为291天后发表。在34%的PROSPERO记录中发现了状态的不一致性。结论：尽管关于区域麻醉的PROSPERO注册有所增加，但大多数尚未发表，三分之一存在状态不准确的问题。