List of the statistically overrepresented Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways obtained for each independent component (IC) after removing first line of variance.

KEGG pathway ID and description is enclosed in the table. Pathway’s main category and subcategory are shown. Gene:Bg Ratio indicates the number of genes annotated to a pathway within the specific list of differential genes among the 509 major contributors that are included in the database (i.e. 201 for IC1) versus the number of genes annotated to a pathway within the background. Background considers all differential genes included in KEGG database which corresponds to 1905 elements among 5084 differential genes. Pathways are sorted based on their adj p-val (FDR correction) coded as *** < 0.001, ** < 0.01 and * < 0.05. Up-reg indicates the percentage of differential genes annotated to the specific pathway being up-regulated.

表格中收录了KEGG通路（KEGG pathway）的ID与描述信息，并展示了对应通路的主类别与子类别。Gene:Bg Ratio（基因/背景比值）指：数据库收录的509个核心贡献基因集合内的差异基因列表中，注释至某通路的基因数（以IC1组为例，该数值为201），与背景基因集中注释至该通路的基因数的比值。此处的背景基因集为所有纳入KEGG数据库的差异基因，即5084个差异基因中的1905个。通路依据经错误发现率（FDR）校正后的P值进行排序，星号标注规则为：***对应P<0.001，**对应P<0.01，*对应P<0.05。Up-reg（上调占比）指注释至该特定通路的差异基因中，上调基因所占的百分比。