Bvul restores Am-depleted dysbiosis: mouse shotgun

Weight loss and exercise intervention studies report an interaction between Bacteroides (Bvul) and Akkermansia (Am), although the underlying mechanism(s) and consequences of the interaction remain unknown. We hypothesized that (1) the interaction is related to obesity, and (2) the role played by Bvul in body weight control and enrichment of Am is both species- and strain-specific.

现有减肥与运动干预相关研究均报道了拟杆菌属（Bacteroides，Bvul）与嗜黏蛋白阿克曼氏菌（Akkermansia，Am）之间存在相互作用，但该相互作用的潜在机制与后续影响仍未阐明。本研究提出两项假说：其一，该相互作用与肥胖存在关联；其二，拟杆菌在体重调控及嗜黏蛋白阿克曼氏菌富集过程中所扮演的角色兼具物种特异性与菌株特异性。