Additional file 3: Table S2. of The endonuclease domain of the LINE-1 ORF2 protein can tolerate multiple mutations

Location of putative phosphorylation sites within the endonuclease domain of L1 ORF2. Putative protein phosphorylation sites within the ORF2 endonuclease domain were identified using the ELM prediction tool [37] and NetPhos 2.0 phosphorylation prediction program [38]. The ELM p-value is a conservative estimate of the probability that an ELM prediction with a given score is a true positive. The significance cut-off is 10e-2. The NetPhos output score is a value in the range of 0.000â 1.000 (the higher the score, the higher the confidence of the prediction). (XLSX 10Â kb)

L1 ORF2核酸酶结构域内推定磷酸化位点的定位。本研究借助ELM预测工具[37]与NetPhos 2.0磷酸化预测程序[38]，成功鉴定出ORF2核酸酶结构域内的推定蛋白质磷酸化位点。其中，ELM的p值为保守估计值，用于表征给定得分的ELM预测结果为真阳性的概率，其显著性截断阈值设为10^-2；NetPhos的输出得分为0.000~1.000区间内的数值，得分越高则预测置信度越高。（XLSX格式，10 KB）