Direct Access to Enantioenriched Spiroacetals through Asymmetric Relay Catalytic Three-Component Reaction

The gold(I)/chiral Brønsted acid relay catalysis enabled a highly stereoselective three-component reaction of salicylaldehydes, anilines, and alkynols to give aromatic spiroacetals in high yields and stereoselectivities.

采用一价金（gold(I)）/手性布朗斯特酸（chiral Brønsted acid）接力催化体系，成功实现了水杨醛（salicylaldehydes）、苯胺（anilines）与炔醇（alkynols）的高立体选择性三组分反应，所得芳香螺缩醛（aromatic spiroacetals）产物具有优异的收率与立体选择性。