Analysis of DNA methylation profiles in colorectal cancer cells treated with boswellic acids. Homo sapiens

Genome wide DNA methylation profiling of colorectal cancer cell lines treated with acetyl-11-keto-β-boswellic acid (AKBA) or 5-aza-2’-deoxycytidine (DAC). The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in the colorectal cancer cell line SW48. Samples included non-treated, AKBA-treated, and DAC-treated SW48 cells. Overall design: Bisulphite converted DNA from the 3 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

本数据集为经乙酰基-11-酮基-β-乳香酸（acetyl-11-keto-β-boswellic acid, AKBA）或5-氮杂-2’-脱氧胞苷（5-aza-2’-deoxycytidine, DAC）处理的结直肠癌细胞系的全基因组DNA甲基化谱分析数据。实验采用Illumina Infinium 27k人类DNA甲基化微珠芯片v1.2，获取了结直肠癌细胞系SW48中覆盖约27000个CpG位点的DNA甲基化谱数据。样本包含未处理、AKBA处理及DAC处理的SW48细胞。实验整体设计：将3份样本的亚硫酸氢盐转化DNA与Illumina Infinium 27k人类甲基化微珠芯片v1.2进行杂交。