Characterization of chemokine and chemokine receptor expression during Pneumocystis infection in healthy and immunodeficient mice (part 1)

For both CD4 and micropajfe cell types, upregulated genes were primarily related to immune activation and proliferation, while down-regulated genes represented more diverse processes, including cell membranes, vasculature development, cell adhesion, and lipid-related metabolic processes. Gene expression microarrays were from 4 exposured samples compared with 4 unexposured samples

针对CD4细胞与巨噬细胞两类细胞，上调基因主要与免疫激活及细胞增殖相关；下调基因则涵盖更为多样的生物学过程，包括细胞膜相关过程、血管发育、细胞黏附以及脂类相关代谢过程。本数据集的基因表达微阵列数据来源于4个暴露组样本与4个未暴露组样本的对照分析。