Genetic basis of drug resistance in Mycobacterium tuberculosis

This dataset consists of files and figures that were used to investigate the genetic basis of drug resistance in Mycobacterium tuberculosis (Mtb). Files Lineage 1.txt - Lineage 6.txt describes the most discriminative polymorphisms needed to differentiate between susceptible and resistant strains. Files Lineage_1_df.txt - Lineage_6_df.txt show all epistatic interactions that exist between the most discriminative polymorphisms. These files also provide the results of the statistical analysis done to ensure that indeed these polymorphisms were epistatically linked. The figures show a network of epistatic interactions that have established evolutionary trajectories towards drug resistance. Common_polymorphisms.v5 shows pseudo sequences of amino acids that were identified among the polymorphisms.Common_polymorphisms.v5_annotation.out shows all the annotated polymorphisms found in Mtb strains. The files_metadata file shows all the drug susceptibility profiles of all Mtb strains included for analysis. Lastly, the universal_AMR_markers show all the markers/indicators of drug resistance to more than three antibiotics.

本数据集包含用于探究结核分枝杆菌（Mycobacterium tuberculosis, Mtb）耐药性遗传基础的各类文件与可视化图表。其中，文件Lineage 1.txt至Lineage 6.txt阐述了区分结核分枝杆菌易感菌株与耐药菌株所需的最具区分效能的多态性位点；文件Lineage_1_df.txt至Lineage_6_df.txt则展示了上述最具区分性多态性位点之间存在的全部上位相互作用（epistatic interactions），同时附带了为验证这些多态性确实存在上位连锁而开展的统计分析结果。配套图表呈现了已明确指向耐药性演化路径的上位相互作用网络。Common_polymorphisms.v5包含了在已鉴定多态性位点中提取的氨基酸伪序列；Common_polymorphisms.v5_annotation.out列出了结核分枝杆菌菌株中所有已注释的多态性位点。files_metadata文件展示了本次分析纳入的全部结核分枝杆菌菌株的药物敏感性谱。最后，universal_AMR_markers包含了可指示对三种以上抗生素产生耐药性的全部耐药标志物。