Open data

The dataset included methylation sequencing data and multiplex droplet digital PCR (mddPCR) assay results for the selected markers For the inhouse primary validation cohort (MethylTarget sequencing), 300 colorectal cancer tissue samples, 58 white blood cell samples and 14 cfDNA samples were collected. For the inhouse cfDNA validation cohort (mddPCR assays), 370 cfDNA samples of colorectal cancer, precancerous lesions, non-CRC patients (benign or malignant tumors of breast or lung) and healthy controls were collected.

本数据集包含针对筛选出的标志物的甲基化测序数据及多重液滴数字PCR（multiplex droplet digital PCR, mddPCR）检测结果。针对内部初始验证队列（采用MethylTarget测序技术），共采集300份结直肠癌组织样本、58份白细胞样本与14份循环游离DNA（cell-free DNA, cfDNA）样本；针对内部cfDNA验证队列（采用mddPCR检测方法），共采集370份来自结直肠癌患者、癌前病变患者、非结直肠癌患者（罹患乳腺或肺良恶性肿瘤者）及健康对照的循环游离DNA样本。