NIHR_Global_Health_Research_Unit_on_Genomic_Surveillance_of_Antimicrobial_Resistance

This project is funded by the UK National Institute for Health Research to set up a full-fledged Global Health Research Unit (GHRU) through a grant awarded to the cGPS (Centre for Genomic Pathogen Surveillance). The aim of this project is primarily to fund research around intelligent surveillance for important emerging bacterial pathogens and monitoring the spread of antimicrobial resistance in low- and middle-income countries (LMICs) through whole-genome sequencing. The proposal would enable bacterial isolates to be collected from several regions around the Philippines, Nigeria, India and Colombia; their genomes assembled and analysed following WGS; not only with the aim of tracking transmission and resistance patterns but eventually in designing models that will integrate into real-time, public health 'early-warning systems'. The study would entail sequencing any isolates as part of R&D SOP testing that can be later implemented at the four GHRU National Units.

本项目由英国国家卫生研究院（UK National Institute for Health Research）资助，通过向基因组病原体监测中心（cGPS, Centre for Genomic Pathogen Surveillance）拨付专项拨款，以设立一所成熟的全球卫生研究单元（GHRU, Global Health Research Unit）。本项目的核心宗旨为：为针对重要新发细菌性病原体的智能监测研究提供资金支持，并借助全基因组测序（WGS, whole-genome sequencing）技术，监测中低收入国家（LMICs, low- and middle-income countries）的抗菌药物耐药性传播态势。本研究计划从菲律宾、尼日利亚、印度及哥伦比亚的多个区域采集细菌分离株，通过全基因组测序完成其基因组组装与分析；此举不仅旨在追踪细菌的传播路径与耐药模式，更致力于最终构建可集成至实时公共卫生"早期预警系统"的预测模型。本研究将对所有采集的分离株进行测序，作为研发标准操作流程（SOP, Standard Operating Procedure）测试的组成部分，该流程后续可在四家GHRU国家单元落地实施。