Precipitation Profiles of Naproxen in Dissolution Media

This dataset contains raw UV absorbance values of naproxen at lambda max (330-334 nm, depending on the polymer), as well as normalised absorbance values (using readings at 850 nm for normalisation). UV spectra of naproxen was taken in a dissolution media consisting of HCl solution with pH 1.2 (prepared according to Ph. Eur.) supplemented with 2.4% acetonitrile (introduced with naproxen solution). The media additionally contained one of the following polymers: povidone (PVP K25), copovidone (Kollidon VA 64), poly (butyl methacrylateco-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate 1:2:1 (Eudragit E PO), polyacrylic acid (Apinovex LV), polyvinyl alcohol (PVAl; SRP, 4-88, and 3-82) at a concentration of 0.75 mg/ml (40:60 drug:polymer), and Soluplus at a concentration of 0.125 mg/ml (80:20 drug:polymer).
Method: A precipitation study was performed in 0.1 N HCl solution with pre-dissolved polymer (60, 40, and 20 wt. %). Naproxen solution in acetonitrile (20 mg/mL) to achieve the proportion of 500 mg of naproxen per 1 L of dissolution medium (0.5 mg/mL) was added. UV absorption was determined directly within 10 mm pathlength quartz cuvettes (at room temperature) with UV spectrophotometer (UV-1900i; Shimadzu Corp., Kyoto, Japan) Spectra were recorded at 5-minute intervals over a 2-hour period (n = 3), using the “Spectrum” or “Time Course” mode in LabSolutions software.
Data. The dataset contains a CSV file of naproxen UV-absorbance values in the presence of polymers. Picture “P1” provides a brief overview of data.

本数据集包含萘普生在其最大吸收波长（λmax，330~334 nm，具体取决于所用聚合物）下的原始紫外吸光度值，以及归一化吸光度值（以850 nm处的吸光度读数作为归一化基准）。萘普生的紫外光谱采集于下述溶出介质：以pH 1.2的盐酸溶液（依照欧洲药典Ph. Eur.制备）为基础溶剂，添加2.4%乙腈（由萘普生储备液引入）。该介质中额外添加以下聚合物之一：聚维酮（PVP K25）、共聚维酮（Kollidon VA 64）、聚(甲基丙烯酸丁酯-co-甲基丙烯酸二甲氨基乙酯-co-甲基甲酯)1:2:1共聚物（尤特奇Eudragit E PO）、聚丙烯酸（Apinovex LV）、聚乙烯醇（PVAl；涵盖SRP 4-88与3-82型号），浓度均为0.75 mg/ml，药物与聚合物质量比为40:60；以及索鲁普斯（Soluplus），浓度为0.125 mg/ml，药物与聚合物质量比为80:20。实验方法：以含预溶解聚合物（质量占比分别为60 wt%、40 wt%与20 wt%）的0.1 N盐酸溶液为介质开展沉淀实验。向介质中加入浓度为20 mg/mL的萘普生乙腈溶液，使最终溶出介质中萘普生浓度达到0.5 mg/mL（即每1升介质含500 mg萘普生）。采用光程10 mm的石英比色皿，于室温下通过紫外分光光度计（UV-1900i；岛津株式会社，日本京都）直接测定紫外吸光度。使用LabSolutions软件的"Spectrum"或"Time Course"模式，在2小时时长内以5分钟为间隔采集光谱，每组实验重复3次（n = 3）。本数据集包含一份记录聚合物存在下萘普生紫外吸光度值的CSV文件。附图"P1"简要概述了该数据集的内容。