Micro-array analysis of wild-type BALB/cByJ mice livers against PMLA220V knock-in mice

Study the impact of the most common mutation on the PML protein found in acute promyeocytic leukemia patients resistant to arsenic therapy, which induces a disorganization of PML nuclear bodies, on gene expression.本研究旨在探究对砷剂治疗耐药的急性早幼粒细胞白血病患者体内检出的早幼粒细胞白血病蛋白（PML protein）最常见突变——该突变可诱导PML核体（PML nuclear bodies）结构紊乱——对基因表达的影响。