Comparison of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in normoglycemic and hyperglycemic subjects

ABSTRACT Objective: To compare the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as possible parameters of systemic inflammation in hyperglycemic and normoglycemic subjects. Methods: A retrospective, cross-sectional study of data collected from patients tested for fasting blood glucose, glycated hemoglobin (HbA1c) and blood count on the same day, between July and December 2016. Patients were divided into hyperglycemic and normoglycemic, and matched by age and sex. The data were analyzed using Epi Info™, version 7.2.1.0, for the Windows® platform. Results: We enrolled 278 subjects, 139 hyperglycemic and 139 normoglycemic. The absolute number of leukocytes and neutrophils was higher in the Hyperglycemic Group (p=0.006 and p=0.004, respectively). There was no difference in the neutrophil-to-lymphocyte ratio between the Hyperglycemic Group and the Normoglycemic Group (2.1 versus 2.0; p=0.264), and both neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios showed no differences between those with HbA1c ≥7% (n=127, p=0.778) and those with HbA1c <7% (n=12, p=0.490). In contrast, the platelet-to-lymphocyte ratio was lower in the Hyperglycemic Group (117.8 versus 129.6; p=0.007). Conclusion: Hyperglycemic subjects had a neutrophil-to-lymphocyte ratio similar to that of normoglycemic subjects, but had a lower platelet-to-lymphocyte ratio. Future prospective studies will be useful to determine the importance and prognostic value of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in the hyperglycemic state.

摘要
研究目的：对比高血糖与血糖正常受试者的中性粒细胞与淋巴细胞比值（neutrophil-to-lymphocyte ratio）及血小板与淋巴细胞比值（platelet-to-lymphocyte ratio）作为全身炎症参数的可行性。
研究方法：本研究为回顾性横断面研究，数据采集自2016年7月至12月期间同日接受空腹血糖、糖化血红蛋白（HbA1c）及血常规检测的患者。将受试者按高血糖与血糖正常分组，并按年龄和性别进行匹配。采用Windows®平台的Epi Info™ 7.2.1.0版本软件对数据进行分析。
研究结果：本研究共纳入278例受试者，其中高血糖组与血糖正常组各139例。高血糖组的白细胞及中性粒细胞绝对计数均高于血糖正常组（分别为p=0.006和p=0.004）。高血糖组与血糖正常组的中性粒细胞与淋巴细胞比值无显著差异（2.1 vs 2.0；p=0.264）；在HbA1c≥7%（n=127）与HbA1c<7%（n=12）的受试者中，中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值均无显著差异（分别为p=0.778和p=0.490）。与之相反，高血糖组的血小板与淋巴细胞比值低于血糖正常组（117.8 vs 129.6；p=0.007）。
研究结论：高血糖受试者的中性粒细胞与淋巴细胞比值与血糖正常受试者相近，但血小板与淋巴细胞比值更低。未来可开展前瞻性研究，以明确高血糖状态下中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值的临床意义与预后价值。