Liver Profiling In HMDP (high-fat/high-sucrose diet)

Identify genes in the liver whose expression is under genetic regulation in the Hybrid Mouse Diversity Panel (HMDP). The HMDP comprises classical inbred and recombinant inbred wild type mice. The RMA values of genes were used for genome wide association as described in Parks et al Cell Metabolism 2015. These data are used to identify candidate genes at loci associated with obesity and dietary responsiveness. GWAS for expression of liver in inbred strains fed chow diet for 8 weeks followed by high-fat/high-sucrose diet 8 weeks本数据集旨在在杂交小鼠多样性面板（Hybrid Mouse Diversity Panel, HMDP）中鉴定表达受遗传调控的肝脏基因。该面板包含经典近交系与重组近交系野生型小鼠。如Parks等人2015年发表于《Cell Metabolism》的研究所述，本研究采用基因的稳健多阵列平均（Robust Multi-array Average, RMA）值开展全基因组关联分析。上述数据可用于定位与肥胖及饮食应答相关的基因座处的候选基因。本数据集还包含针对近交系小鼠肝脏表达的全基因组关联分析（Genome-Wide Association Study, GWAS）数据：这些小鼠先饲喂标准饲料8周，随后更换为高脂高蔗糖饲料饲喂8周。