Rh-Catalyzed Synthesis of Helically Chiral and Ladder-Type Molecules via [2 + 2 + 2] and Formal [2 + 1 + 2 + 1] Cycloadditions Involving C−C Triple Bond Cleavage

We have developed highly enantioselective synthesis of functionalized helically chiral molecules via a Rh-catalyzed [2 + 2 + 2] cycloaddition and synthesis of ladder-type molecules via an unprecedented Rh-catalyzed formal [2 + 1 + 2 + 1] cycloaddition involving C−C triple bond cleavage.

我们开发了两类合成策略：其一通过铑（Rh）催化的[2+2+2]环加成反应，实现官能化螺旋手性分子的高对映选择性合成；其二通过一种前所未有的、涉及碳碳三键断裂的铑（Rh）催化形式上的[2+1+2+1]环加成反应，完成梯形分子的合成。