The effect of Lactobacillus on intestinal microbiota in ALD mice

Excessive alcohol intake disrupts gut microbiota homeostasis, facilitating lipopolysaccharide (LPS) translocation into circulation, which drives hepatic inflammation. Concurrently, chronic alcohol consumption impairs lipid metabolism, exacerbating the progression of alcoholic fatty liver disease. Notably, ethanol metabolism generates acetaldehyde and reactive oxygen species (ROS) via redox imbalances, further promoting oxidative stress and pro-inflammatory cascades. In this study, we investigated the therapeutic potential of Lactobacillus acidophilus (Lac) in mitigating ALD.Our results demonstrate that Lac administration restores gut microbial composition, enhances intestinal barrier integrity, reduces LPS leakage, and ultimately alleviates ALD injury.

过量饮酒会破坏肠道菌群稳态，促进脂多糖（LPS）易位进入循环系统，进而引发肝脏炎症。与此同时，长期饮酒会损伤脂质代谢，加剧酒精性脂肪肝疾病（ALD）的进展。值得注意的是，乙醇代谢会通过氧化还原失衡产生乙醛与活性氧（ROS），进一步推动氧化应激与促炎症级联反应的发生。本研究探讨了嗜酸乳杆菌（Lac）在缓解ALD方面的治疗潜力。研究结果显示，补充嗜酸乳杆菌可恢复肠道菌群组成，增强肠道屏障完整性，减少LPS渗漏，最终减轻ALD损伤。