Additional file 2: of Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner

Associations of candidate gene expression in fetal placenta with maternal U-As. Multivariable linear regression analysis was performed to determine the association between log-transformed maternal U-As and log-transformed fetal placental expression of epigenetic candidate genes, in A) the unstratified cohort, B) males, and C) females. Analyses were adjusted for maternal age at enrollment. P values before and after FDR adjustment are shown (columns C-D). The effect of adjustment for urinary creatinine was also determined, by comparing the standardized beta values obtained from the subset of participants for which urinary creatinine data were available (â standardized_subset_betaâ , column P) with the equivalent values after adjustment for urinary creatinine (â standardized_subset_betaâ , column Q). Results of goodness-of-fit tests are also shown (columns S-T). (XLSX 124 kb)

胎儿胎盘候选基因表达与母体尿砷（Urinary Arsenic，U-As）的关联。本研究采用多元线性回归分析，探究经对数转换后的母体尿砷与经对数转换的胎儿胎盘表观遗传候选基因表达量之间的关联，分析场景分为A）未分层队列、B）男性亚组及C）女性亚组。所有分析均针对入组时的母体年龄进行了校正。经错误发现率（False Discovery Rate，FDR）校正前后的P值已在C至D列中予以呈现。本研究同时通过对比纳入尿肌酐数据的参与者亚组所得到的标准化β值（标记为“standardized_subset_beta”，对应P列）与经尿肌酐校正后的等效标准化β值（标记为“standardized_subset_beta”，对应Q列），明确了尿肌酐校正的影响效应。拟合优度检验（Goodness-of-fit test）的结果同样在S至T列中展示。（XLSX格式，文件大小124 KB）