Ugonin inhibits chondrosarcoma metastasis through suppressing cathepsin V via promoting miR-4799-5p expression

Chondrosarcoma is a rare type of bone cancer that develops in cartilage cells. Ugonin V is a flavonoid compound that has been extracted from the plant Helminthostachys zeylanica (L.) Hook. This study examined the molecular therapeutic effects of ugonin V on chondrosarcoma metastasis. Overall design: To identify differentially expressed miRNAs regulated by Ugonin V, JJ012 cells were treated with Ugonin V (10 µM) for 24 h in the culture medium, and miRNA sequencing was performed.

软骨肉瘤（Chondrosarcoma）是一种罕见的骨恶性肿瘤，起源于软骨细胞。次乌头素V（Ugonin V）是一种提取自七指蕨（Helminthostachys zeylanica (L.) Hook.）的黄酮类化合物。本研究探讨了次乌头素V对软骨肉瘤转移的分子治疗作用。整体实验设计：为鉴定次乌头素V调控的差异表达微小RNA（microRNA, miRNA），将JJ012细胞置于培养基中，以10 μM浓度的次乌头素V处理24小时，随后进行miRNA测序。