Effect of osteocytes mitochondria on OA chondrocytes

To investigate the regulatory role of MLO-Y4 mitochondria on OA chondrocytes, we isolated mitochondria from MLO-Y4 and transplanted to chondrocytes treated with IL-1β. We then performed gene expression profiling analysis using data obtained from RNA-seq of chondrocytes from vehicle group and mitochondria transplanted group. Comparative gene expression profiling analysis of RNA-seq data for OA chondrocytes and OA chondrocytes transplanted with mitochondria.

本数据集旨在探究MLO-Y4线粒体对骨关节炎（Osteoarthritis, OA）软骨细胞的调控作用：我们从MLO-Y4细胞中分离线粒体，并将其移植至经白细胞介素-1β（Interleukin-1β, IL-1β）处理的软骨细胞中；随后基于载体对照组与线粒体移植组软骨细胞的RNA测序（RNA-seq）数据开展基因表达谱分析。本数据集针对骨关节炎软骨细胞及移植了线粒体的骨关节炎软骨细胞的RNA-seq数据，完成了对比性基因表达谱分析。