Genomic approach to transmission and compartmentalization of extended-spectrum cephalosporin resistance (ESC-R) in Enterobacterales of animal and human origin from North America and Europe. Distribution and dynamics of extended-spectrum cephalosporin resistance (ESC-R) in Enterobacterales

The emergence and persistence of extended-spectrum cephalosporin resistance (ESC-R) is a major public health problem worldwide. This study aimed to investigate the distribution and the temporal dynamics of ESC-R genes in Enterobacterales isolates of human and animal origin from North America and Europe, including Escherichia coli (n=1,377), Klebsiella pneumoniae (n=46), Enterobacter hormaechei (n=11), Salmonella enterica (n=3), Klebsiella oxytoca (n=3), Proteus mirabilis (n=3), Klebsiella michiganensis (n=2), Raoultella ornithinolytica (n=1), Citrobacter freundii (n=1) and Citrobacter europaeus (n=1). All isolates were sequenced on an Illumina MiSeq or HiSeq or NextSeq instrument.

超广谱头孢菌素耐药性（extended-spectrum cephalosporin resistance, ESC-R）的出现与持续存在是全球范围内的重大公共卫生问题。本研究旨在调查北美与欧洲来源的人源及动物源肠杆菌目（Enterobacterales）分离株中ESC-R基因的分布特征与时间动态，所涉分离株包括：大肠埃希氏菌（Escherichia coli，n=1377）、肺炎克雷伯菌（Klebsiella pneumoniae，n=46）、霍氏肠杆菌（Enterobacter hormaechei，n=11）、肠炎沙门氏菌（Salmonella enterica，n=3）、产酸克雷伯菌（Klebsiella oxytoca，n=3）、奇异变形杆菌（Proteus mirabilis，n=3）、密歇根克雷伯菌（Klebsiella michiganensis，n=2）、鸟氨酸劳特罗普菌（Raoultella ornithinolytica，n=1）、弗氏柠檬酸杆菌（Citrobacter freundii，n=1）以及欧洲柠檬酸杆菌（Citrobacter europaeus，n=1）。所有分离株均通过Illumina MiSeq、HiSeq或NextSeq测序仪完成测序。