Cholinergic Anti-inflammatory Pathway (CAP) Activation in a Model of Acute Lung Infection

The cholinergic anti-inflammatory pathway (CAP), has been well-studied and shown to control peripheral cytokine levels and inflammation. This nerve pathway has been activated pharmacologically or by nerve stimulators and studied in animal models and clinical studies. However, these CAP investigations have typically been performed in models or study populations of severe systemic or pathological inflammation. This transcriptomic profiling study was conducted in rats to understand CAP in a model of actue lung infeaction. Splenic ultrasound stimulation was used to activate CAP in both healthy animals and animals with an acute lung infection.胆碱能抗炎通路（cholinergic anti-inflammatory pathway, CAP）已得到广泛研究，被证实可调控外周细胞因子水平与炎症反应。该神经通路可通过药理学手段或神经刺激器激活，并已在动物模型与临床研究中得到探究。然而，现有针对CAP的研究通常仅针对重度全身性炎症或病理性炎症的模型与研究人群开展。本转录组分析（transcriptomic profiling）研究以大鼠为实验对象，旨在探究急性肺部感染模型中的胆碱能抗炎通路作用机制。研究中，分别对健康大鼠与急性肺部感染模型大鼠采用脾脏超声刺激的方式以激活CAP。