Supplementary Material for: Hypoalbuminemia and generalized edema as the presenting symptoms of celiac disease in a two-year-old girl – case report

Celiac disease is a systemic, immune-mediated enteropathy that occurs following dietary consumption of gluten in genetically susceptible individuals. The global prevalence of celiac disease is estimated to be approximately 1.4%, with variation based on age, sex, and geographic location. Celiac disease typically presents early in life with diarrhea, abdominal pain, abdominal distention, weight loss, and impaired growth. In severe cases, patients with celiac disease can present in a state of celiac crisis, classically characterized with profuse diarrhea and life-threatening metabolic derangements. In this report, we discuss a 23-month-old girl who presented atypically with hypoalbuminemia and generalized edema.

乳糜泻（Celiac disease）是一种全身性免疫介导性肠病，仅在遗传易感个体摄入麸质饮食后发病。据估算，乳糜泻的全球患病率约为1.4%，且患病率会随年龄、性别及地理位置存在差异。乳糜泻通常在幼年起病，表现为腹泻、腹痛、腹胀、体重减轻及生长发育迟缓。病情严重时，患者可出现乳糜危象，典型特征为大量腹泻及危及生命的代谢紊乱。本报告将介绍一例23月龄女童，其以低白蛋白血症和全身性水肿为非典型表现起病。