Accessing 1,3-Dienes via Palladium-Catalyzed Allylic Alkylation of Pronucleophiles with Skipped Enynes

An unprecedented palladium-catalyzed
allylic alkylation of pronucleophiles
with unactivated skipped enynes has been developed. This method provides
a straightforward access to a wide array of 1,3-dienes without the
need to preinstall leaving groups or employ extra oxidants. The reaction
exhibited high atom economy, good functional group tolerance, excellent
regioselectivities, and scalability. With D2O as cosolvent,
deuterium could be incorporated in high efficiency.

本研究开发了一种前所未有的钯催化亲核前体（pronucleophile）与未活化跳过型烯炔（skipped enyne）的烯丙基烷基化反应。该方法可便捷合成一系列1,3-二烯烃类化合物，无需预先安装离去基团，亦无需使用额外氧化剂。该反应具有优异的原子经济性、良好的官能团耐受性、出色的区域选择性与可放大性。以重水（D₂O）作为共溶剂时，可高效引入氘原子。