UCD Cleft primary palate 4.9 Mb candidate region targeted sequencing

Birds of the congenic inbred chicken line UCD Cleft primary palate (UCD cpp.003) carry an autosomal recessive mutation observed as a lethal developmental defect in affected homozygous mutant progeny. This mutation was mapped to a 4.9 Mb region of chromosome 11, and is sequenced in this project in several individuals of the UCD cpp.003 line with the aim of assessing variation linked to the mutation, and ultimately determining the causative element.

乌尔丁顿同基因近交鸡系UCD Cleft初级腭（UCD cpp.003）携带一个常染色体隐性突变，该突变表现为受影响纯合突变后代的致死性发育缺陷。该突变定位在11号染色体上的4.9兆碱基区域，本项目旨在通过分析UCD cpp.003系多个个体中的突变相关变异，最终确定致病基因。