Concentrations of selected analytes in mainstream smoke of commercial cigarettes to which 13C-labeled and unlabeled sugars were added.

[13C]-isotope labeled sugars were added to cigarettes. Different concentrations, sugars (fructose, glucose, sucrose, and a mixture) were tested with eight cigarette brands, with different design characteristics such as length and filter ventilation and sugar content. Cigarettes were machine-smoked (using ISO and WHO Intense regimes), and the resulting samples were subjected to untargeted and targeted analyses (for volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs), aldehydes, tobacco-specific nitrosamines (TSNAs) and nicotine).本研究将[13C]同位素标记糖类（[13C]-isotope labeled sugars）添加至卷烟中。针对八种具备不同设计特征（包括长度、过滤嘴通风率及糖含量）的卷烟品牌，测试了不同浓度的糖类样本（果糖、葡萄糖、蔗糖及混合糖）。采用ISO标准与WHO强化抽吸方案对卷烟进行机械抽吸，随后对所得样品开展非靶向与靶向分析，检测指标涵盖挥发性有机化合物（volatile organic compounds, VOCs）、多环芳烃（polycyclic aromatic hydrocarbons, PAHs）、醛类、烟草特有亚硝胺（tobacco-specific nitrosamines, TSNAs）以及尼古丁。