CD49f defines a subset of dysfunctional regulatory T cells circulating in the human peripheral blood. CD49f defines a subset of dysfunctional regulatory T cells circulating in the human peripheral blood

Integrin CD49f has been reported to modulate various aspects of T cell biology including cell differentiation, migration and functionality. Here we define CD49f as a marker for a subset of dysfunctional human effector Tregs expressing a Th17-like profile in the blood of patients with active inflammatory bowl disease. Overall design: RNA profiles of CD49f high and low Tregs extracted from healthy donor peripheral blood mononuclear cells (PBMC).

整合素CD49f（Integrin CD49f）已有研究证实可调控T细胞生物学的多个方面，涵盖细胞分化、迁移与功能发挥。本研究明确整合素CD49f可作为活动性炎症性肠病患者血液中一群表达Th17样表型的功能失调人效应性调节性T细胞亚群的标志物。实验整体设计：对从健康供者外周血单个核细胞（PBMC）中分离的CD49f高表达与低表达调节性T细胞开展RNA表达谱分析。