HG-IMA (Raw data)

Background Ischemia and associated hypoxemia-induced oxidative stress play an important role in the pathogenesis of hyperemesis gravidarum. Objective The aim of this study was to investigate the role of ischemia-modified albumin in the prediction of hyperemesis gravidarum. Methods A prospective cohort study was conducted with 138 eligible participants with singleton pregnancies who had experienced hyperemesis gravidarum in previous pregnancies. Blood samples were taken from the participants ≤5th week of pregnancy, provided they had no symptoms of nausea and vomiting at that time. The samples were stored under appropriate conditions to be analyzed for ischemia-modified albumin in due course. All participants were then followed to determine whether they would develop hyperemesis gravidarum. Results ​Hyperemesis gravidarum occurred in 42 of the 138 participants (hyperemesis gravidarum group), while the remaining 96 participants did not develop hyperemesis gravidarum (control group). Baseline characteristics showed no significant differences. Ischemia-modified albumin levels were significantly higher in the hyperemesis gravidarum group (p<0.001). Ischemia-modified albumin levels did not correlate with body mass index or maternal age. Ischemia-modified albumin with a cut-off of >74.74 ng/mL (95% sensitivity, 67% specificity) had a discriminatory power with an AUC value of 0.791 (95% CI: 0.714-0.856; p<0.001) for predicting hyperemesis gravidarum. Conclusion Our results show an association between high ischemia-modified albumin levels in early pregnancy and an increased risk of hyperemesis gravidarum. ischemia-modified albumin can be used as a predictive tool for hyperemesis gravidarum.

背景：缺血及相关低氧血症诱导的氧化应激在妊娠剧吐（hyperemesis gravidarum）的发病机制中发挥重要作用。
目的：本研究旨在探讨缺血修饰白蛋白（ischemia-modified albumin）在妊娠剧吐预测中的应用价值。
方法：本研究为前瞻性队列研究，纳入138名既往有妊娠剧吐病史的单胎妊娠合格受试者。于受试者妊娠≤5周且无恶心呕吐症状时采集血液样本，将样本置于适宜条件下保存，以待后续检测缺血修饰白蛋白水平。随后对所有受试者进行随访，以明确其是否发生妊娠剧吐。
结果：138名受试者中，42名发生妊娠剧吐，归入妊娠剧吐组；剩余96名未发生妊娠剧吐，归入对照组。两组基线特征无显著差异。妊娠剧吐组的缺血修饰白蛋白水平显著高于对照组（p<0.001）。缺血修饰白蛋白水平与体质量指数及产妇年龄无相关性。当缺血修饰白蛋白截断值设定为>74.74 ng/mL时，其预测妊娠剧吐的敏感性为95%、特异性为67%，曲线下面积（AUC）为0.791（95%置信区间CI：0.714~0.856；p<0.001），具有良好的区分效能。
结论：本研究结果显示，妊娠早期缺血修饰白蛋白水平升高与妊娠剧吐风险增加存在显著关联，缺血修饰白蛋白可作为妊娠剧吐的预测工具。