Cell survival and interactions of all drug combinations in the present study.

Viability was measured using the neutral read assay. 5% CI and 95% CI mark 5% and 95% confidence intervals from bootstrapping. Interaction is I = log(1 + viability − Bliss) where Bliss is the product of the single-drug viability values. Antagonism and synergy are marked in blue and pink and denote cases where I > 0 or I < 0 together with the demand that I = 0 is outside the 95% confidence interval. Cocktails in bold are synergistic/antagonistic for both cell lines.

细胞活力采用中性读数测定法（neutral read assay）进行检测。5%置信区间（5% CI）与95%置信区间（95% CI）标识了通过自举法（bootstrapping）计算得到的5%与95%置信区间。相互作用指数I的计算公式为$I = log(1 + ext{viability} - ext{Bliss})$，其中Bliss值为单药活力值的乘积。拮抗作用与协同作用分别以蓝色与粉色标记，分别对应$I > 0$与$I < 0$的情况，且需满足$I=0$处于95%置信区间之外。以粗体标注的药物联用组合对两种细胞系均表现出协同或拮抗效应。