Expression profiling feline peripheral blood monocytes identifies a transcriptional signature associated with type two diabetes mellitus

Peripheral blood monocytes were isolated from 3 control and 3 diabetic cats using positive selection and expression profiled using the Affymetrix Feline 1.0ST array. Comparison of monocyte expression in cats with type 2 diabetes or controls (n=3 per group)

本研究采用阳性筛选法，从3只健康对照猫与3只2型糖尿病猫体内分离外周血单核细胞（peripheral blood monocytes），并通过Affymetrix猫类1.0ST基因芯片（Affymetrix Feline 1.0ST array）进行表达谱分析。本研究对2型糖尿病猫与健康对照组（每组n=3）的单核细胞基因表达谱开展了比较分析。