Structural Biology in Marseille

Our BAG groups 8 teams from 4 Marseille laboratories. Research themes deal with infection, health and biotechnology. For 107 projects within this proposal we foresee 10 MX and 2 SAXS shifts for the next beam time allocation period. This amount of beam time reflects what we had asked for in the previous proposal round. Two teams of the BAG combine structural biology with medicinal chemistry and beam time at MASSIF for large ligand-screening campaigns will mostly suit their research purposes. Access to beamlines with tuneable energy will be instrumental for projects requiring phasing by MAD or MIRAS. One team uses exclusively Bio-SAXS and allocation of one shift/session would be welcomed. Remote access for MX sessions has become very popular whereas scientists prefer to be on-site for Bio-SAXS experiments. We are grateful to the ESRF staff for always being forthcoming with regard to scheduling, logistics and experiments, allowing the BAG to produce good Science in a comfortable setting.

我们的BAG由来自马赛4个实验室的8支团队组成，研究主题涵盖感染、健康与生物技术领域。针对本提案中的107个项目，我们预计在下一轮光束时间分配周期内申请10个大分子晶体学（MX）和2个小角X射线散射（SAXS）班次。该光束时间总量与上一轮提案中的申请规模一致。BAG中的两支团队将结构生物学与药物化学相结合，MASSIF光束线的时间分配将主要满足其大规模配体筛选研究的需求。对于需要通过多波长反常散射（MAD）或多同晶置换反常散射（MIRAS）进行相位解析的项目而言，可调谐能量光束线的使用至关重要。有一支团队仅采用生物小角X射线散射（Bio-SAXS）技术，因此分配一个班次/场次的时间将是他们所期望的。MX实验的远程访问已广受欢迎，但科学家们更倾向于亲临现场开展Bio-SAXS实验。我们衷心感谢欧洲同步辐射装置（ESRF）工作人员在日程安排、后勤保障及实验支持方面始终给予的鼎力相助，使BAG能够在良好的环境中开展高质量的科学研究。