The mechanism of HHT in treating acute myeloid leukemia on RNA level.

Through the GSEA analysis, we identified the suppressed E2F targets, G2M checkpoints, and hyperactivated p53 pathway after HHT treatment. Overall design: Two cell lines with PBS and two drug concentrations.

我们通过基因集富集分析（Gene Set Enrichment Analysis，GSEA）鉴定得到，经高三尖杉酯碱（Homoharringtonine，HHT）处理后，表达受抑的E2F靶点 (E2F targets)、G2M检查点 (G2M checkpoints) 以及过度激活的p53通路 (p53 pathway)。整体实验设计：共设置两种细胞系，每组均设置磷酸盐缓冲液（Phosphate Buffered Saline，PBS）对照与两种不同浓度的HHT处理组。