Frequency of 374F (rs16891982) and the A allele (intronic rs35397) in a) the most pigmented (Dark) and least pigmented (Light) individuals of the skin reflectance distribution from our study and in b) the populations from 1KGP.

n: number of chromosomes.1North Europe: CEU (Utah residents with Northern and Western European Ancestry, n = 174), GBR (British in England and Scotland, n = 176) and FIN (Finnish in Finland, n = 186).2South Europe: TSI (Toscani in Italy, n = 196) and IBS (Iberian in Spain, n = 28).

n：染色体数目。1. 北欧人群：CEU（拥有北欧与西欧血统的犹他州居民，n=174）、GBR（英格兰与苏格兰裔英国人，n=176）及FIN（芬兰本土芬兰人，n=186）。2. 南欧人群：TSI（意大利托斯卡纳人，n=196）及IBS（西班牙伊比利亚人群，n=28）。