Supplementary Material for: Treatment satisfaction and treatment wishes of patients with chronic cancer-related pain

Purpose Up to 40% of long-term cancer survivors suffer from chronic cancer-related pain (CCRP) with often inadequate treatment. CCRP is influenced by biopsychosocial factors, with interdisciplinary multimodal pain therapy (IMPT) being a comprehensive treatment option. In our study, patients with CCRP were asked about their treatment satisfaction and treatment wishes. Methods Two anonymous online surveys on CCRP in long-term survivors were analyzed: Survey 1 from cancer self-help group members and Survey 2 from patients with CCRP assessed at the Interdisciplinary Pain Centre (IPC), resulting in recommendations ranging from outpatient treatment to IMPT. Results 38 members of 8 self-help groups in Survey 1 and 50 of 158 patients with CCRP in Survey 2 completed the questionnaire. In both surveys, relevant pain impairment and pain therapy dissatisfaction were identified. A higher intensity of therapy, including the implementation of IMPT, did not lead to better pain control. Consistent with the biopsychosocial factors in CCRP, increased depression scores and increased treatment dissatisfaction correlated. In both surveys participants expressed extensive therapy wishes. Conclusions Despite comprehensive therapeutic approaches, long-term survivors with CCRP suffer from severe pain and treatment dissatisfaction. Biopsychosocial influences are evident, with depression worsening treatment satisfaction. Classical IMPT for CCRP may not be targeted enough and a more specific therapeutic approach should be developed and must be tested using PROMs (patient-reported outcome measures).

研究背景与目的 多达40%的长期癌症幸存者会遭受慢性癌痛（chronic cancer-related pain, CCRP）的困扰，且现有治疗往往效果不佳。慢性癌痛受生物-心理-社会因素影响，跨学科多模式疼痛治疗（interdisciplinary multimodal pain therapy, IMPT）是一种综合治疗方案。本研究针对慢性癌痛患者的治疗满意度与治疗诉求展开调研。

研究方法 本研究对两项针对长期癌症幸存者慢性癌痛的匿名在线调研数据进行分析：调研1招募自癌症自助组织成员，调研2招募自跨学科疼痛中心（Interdisciplinary Pain Centre, IPC）确诊的慢性癌痛患者，调研涵盖从门诊治疗到跨学科多模式疼痛治疗的各类推荐方案。

研究结果 调研1共回收8个自助小组的38份有效问卷，调研2共从158名慢性癌痛患者中回收50份有效问卷。两项调研均显示，受试者存在显著的疼痛功能损害与疼痛治疗不满情绪。提升治疗强度（包括实施跨学科多模式疼痛治疗）并未带来更好的疼痛控制效果。与慢性癌痛的生物-心理-社会致病机制相符，抑郁评分升高与治疗满意度降低呈显著相关。两项调研的受试者均表达了广泛的治疗诉求。

研究结论 尽管采用了综合治疗方案，长期癌症幸存者群体的慢性癌痛患者仍承受着严重疼痛困扰，并存在治疗满意度低下的问题。生物-心理-社会因素的影响显著，其中抑郁症状会进一步降低治疗满意度。现有针对慢性癌痛的经典跨学科多模式疼痛治疗或许缺乏足够的针对性，亟需开发更具特异性的治疗方案，并通过患者报告结局指标（patient-reported outcome measures, PROMs）开展相关验证研究。